The Duke of York gives up his designation as Duke of York.
The royal is giving up his honors, such as the York's Duke, he has announced in a individual message.
He has been under increasing pressure over his associations with convicted criminal the financier, with calls for the Palace to take action against him.
That now appears to have caused the prince deciding to of his own accord give up his titles and to relinquish participation of the prestigious order.
In his announcement he said he continued to "vigorously deny the claims against me".
"In talks with the sovereign, and my direct and broader family, we have agreed the ongoing allegations about me take away from the duties of the monarch and the monarchy," said a message from Prince Andrew.
"I have decided, as I always have, to put my obligation to my kin and country first.
"I uphold my choice five years ago to withdraw from royal engagements.
"With His Majesty's consent, we believe I must now go a step further. I will therefore no longer employ my title or the awards which have been conferred upon me. As I have said earlier, I vigorously deny the accusations against me."
He has faced a range of scandals, including a lawsuit he settled with an accuser, doubts about his economic affairs and his connection with an accused foreign agent.
He will stay a member of royalty - but will stop to be the York's Duke, a designation granted from his the late Queen, the Queen Elizabeth II.
The prince had already ceased to be a "active member" and had given up the use of his royal style and no longer was seen at public engagements. His status now will be even more diminished.
His former spouse will be known as Ferguson and no longer the Duchess, but their daughters will carry on to have the title of princesses.
The royal has faced intense scrutiny over his associations with convicted sex offender Epstein, more recently involving inquiries about when he had truly cut off ties.
In his BBC Newsnight interview, Prince Andrew had said that he had severed all ties with Epstein after they had been photographed together in NYC in late 2010.
But messages sent in February 2011 later surfaced indicating that Andrew had in private remained in communication with him, such as exchanging a message: "Remain connected and we'll meet again soon!"
There had been mounting displeasure in the monarchy at the issues that remained to plague the figure.
Soon a posthumous memoir by the accuser will be issued which is expected to draw further focus on the royal's connection with Ms Giuffre and the financier.